Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human CD40
This gene belongs to the TNF-receptor superfamily and encodes a receptor on immune system antigen-presenting cells It mediates various immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation AKNA transcription factor regulates the receptor and its ligand important for homotypic cell interactions The adaptor protein TNFR2 mediates signal transduction The receptor-ligand interaction is essential for amyloid-beta-induced microglial activation potentially playing a role in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported
ABclonal Technology 488 Rabbit anti-Human CD300c
The CMRF35 antigen which was identified by reactivity with a monoclonal antibody is present on monocytes neutrophils and some T and B lymphocytes (Jackson et al 1992 [PubMed 1349532])
ABclonal Technology 488 Rabbit anti-Human CD116
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2 a cytokine which controls the production differentiation and function of granulocytes and macrophages The encoded protein is a member of the cytokine family of receptors This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes Multiple transcript variants encoding different isoforms have been found for this gene with some of the isoforms being membrane-bound and others being soluble
ABclonal Technology 647 Rabbit anti-Human CD66b
Enables protein heterodimerization activity Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Located in cell surface and extracellular space Biomarker of severe acute respiratory syndrome
ABclonal Technology 647 Rabbit anti-Human CD200R
This gene encodes a receptor for the OX-2 membrane glycoprotein Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner Alternative splicing of this gene results in multiple transcript variants
ABclonal Technology 450 Rabbit anti-Human CD59
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis and it is involved in lymphocyte signal transduction This protein is a potent inhibitor of the complement membrane attack complex whereby it binds complement C8 and or C9 during the assembly of this complex thereby inhibiting the incorporation of multiple copies of C9 into the complex which is necessary for osmolytic pore formation This protein also plays a role in signal transduction pathways in the activation of T cells Mutations in this gene cause CD59 deficiency a disease resulting in hemolytic anemia and thrombosis and which causes cerebral infarction Multiple alternatively spliced transcript variants which encode the same protein have been identified for this gene
ABclonal Technology 647 Rabbit anti-Human Syk
This gene encodes a member of the family of non-receptor type Tyr protein kinases This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses including proliferation differentiation and phagocytosis It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human AXL
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal followed by two fibronectin type-III motifs It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6) This gene may be involved in several cellular functions including growth migration aggregation and anti-inflammation in multiple cell types The encoded protein acts as a host cell receptor for multiple viruses including Marburg Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus
ABclonal Technology 450 Rabbit anti-Human EGFR
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation Mutations in this gene are associated with lung cancer EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
Human IGHG1 PAb 100ul (Sino Biological)
Produced in rabbits immunized with recombinant human IgG1-Fc (Catalog#10702-HNAH; P01857-1; Glu99-Lys330,C103S). This polyclonal antibody was purified by antigen affinity chromatography.